1.   A rationing system would be a major step backwards.

2.   And they knew that learning was a way out of the trap, a major step toward self-expression.

3.   But I hope that this election will be a major step toward that ultimate goal.

4.   Certain lizards take the spiky defence trend a major step further, with long, sharp spines growing out of their scaly skins.

5.   Later writers would often have us believe that all the major steps were taken very early on.

6.   Our next major step was to sort out a name.

7.   Several opposition leaders described the programme as a major step backwards for democracy.

8.   Silicone lubricant enhances recovery of nucleic acids after phenol-chloroform extraction Phenol-chloroform extraction is a major step in the purification of nucleic acids.